Scientist I - Bio Process Purification Development

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

The Biologics CMC Development team at AbbVie in the Bay Area has a long and rich history of biologics development. Now located in a new state of the art facility in South San Francisco, the team leverages its comprehensive end-to-end CMC capabilities to work collaboratively through all phases of CMC development with a primary focus on advancing complex biologic therapies, such as bi-specifics and novel modalities, to human clinical studies and eventual licensure. This Scientist I role is within a team of highly experienced scientists and managers who have directly enabled the development/IND submissions of 20+ novel oncology drugs and successfully filed two BLAs.

As a CMC purification development scientist, you will independently design, execute, and interpret experiments to develop robust, phase-appropriate purification processes for drug substance GMP production to enable human clinical studies and eventual licensure. This position is an onsite, lab-based role requiring close collaboration and daily face-to-face interactions with scientists.

Responsibilities:

Develop, optimize, and scale up purification processes for monoclonal antibodies, multi-specifics, antibody-like molecules, and other complex biologic candidates across early- and late-stage drug substance process development; independently design and execute experiments, interpret results, and recommend next steps.

Support transfer of purification processes to GMP manufacturing sites for clinical material production, including preparation of technical documentation.

Evaluate novel, advanced bioprocess technologies that are in line with the group’s strategy

Plan and execute laboratory and scale-up activities efficiently, collaborating within the team and cross-functionally to meet project timelines and goals.

Work with contract laboratories to plan and execute assigned viral clearance studies, interpret results, and contribute to technical documentation.

Author technical reports and maintain complete, traceable experimental and batch records, including instrument and analytical data, in approved electronic systems; document results at execution and follow established procedures and timelines.

Prepare and deliver technical presentations and group-meeting updates; critically evaluate experimental results, communicate recommendations, and promptly document and communicate significant deviations or unexpected results

Follow applicable laboratory and scale-up facility safety procedures and standard operating procedures (SOPs), complete required training before performing assigned activities, and contribute to laboratory readiness through equipment maintenance, cleanliness, and inventory management

Qualifications

Bachelor’s degree with 5+ years of relevant industry experience or Master’s degree with typically 2+ years of relevant industry experience (in Chemical Engineering, Biochemistry, Chemistry, or a closely related field, preferred)

Must have protein purification experience including chromatography separations and filtration operations

Excellent attention to detail; ability to follow written experimental protocols and safety procedures and maintain accurate, complete, and traceable written records

Demonstrated ability to independently design, execute, and interpret critical experiments to answer scientific questions, troubleshoot purification operations, and recommend next steps

Demonstrated ability to learn, understand and master new experimental techniques

Able to work collaboratively within and outside of the group

Able to author technical reports and presentations

Has understanding of biochemistry and bioprocess engineering concepts

Strong planning and analytical skills, including the ability to critically evaluate experimental results and identify, document, and communicate significant deviations or unexpected results

Experience with AKTA chromatographic instruments (such as AKTA Avant, AKTA Purifier, AKTA Pure or similar)

Demonstrated scientific writing skills and strong verbal communication skills including scientific data presentations

Proficiency with Microsoft Office and the ability to learn new software applications for experimental documentation, data analysis, and reporting

Preferred:

Has hands on experience with executing antibody or antibody-like molecule purification techniques including resin chromatography (affinity, CEX, AEX, MMC), depth filtration, virus filtration, membrane chromatography, and TFF operations.

Has hands on experience with monoclonal antibody or antibody-like molecule purification at GMP, pilot and/or laboratory scale

Understanding of analytical techniques, such as HPLC, LAL, and ELISA

Has hands on experience with high-throughput technologies and automation

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at  the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors  including  geographic location, and we may ultimately  pay more or less than the posted range. This range may be  modified in the future. ​

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

This job is eligible to  participate in our short-term incentive programs.  ​

Note: No amount of pay is  considered to be wages or compensation until such amount is earned,  vested,  and determinable. The amount and availability of  any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a   particular employee  remains in the Company's sole and absolute discretion unless and until paid and may be  modified at the Company’s sole and absolute discretion,  consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

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